• Hosseini, Seyed Saeid
• Ulbricht, Mathias
• Denayer, Joeri
• Mostafavi, Amir Hossein
• Mishra, Ajay Kumar

Abstract

Ever-increasing demands for high performance blood oxygenators have led to continuous advancements in this field.Despite the progresses made since their emergence, there still exist challenges that intimidate the reliability ofmembrane oxygenators. A promising approach for addressing these challenges and enhancing the overall processperformance relates to the selection, development, and modification of materials with desirable characteristics. The mainimpetus for the present review is to bring forward important and yet less explored subjects by shedding light on thetechnological, design, and engineering aspects of oxygenators and the oxygenation process. Special attention is paid tomembrane oxygenators and their essential characteristics such as gas transport, plasma leakage, and biocompatibility.Also, various practical configurations of membrane oxygenators are illustrated with their merits and limitations. From thematerials perspective, a comprehensive range of polymeric materials with track records for applications as membraneoxygenators are surveyed and analyzed considering their physicochemical and biocompatibility properties in order togain insights into the features of an optimal material. In addition to elaborations on the methods for fabrication ofmembrane oxygenators, various effective techniques that could be used for altering the microstructure and surfaceproperties of the membranes are presented. Also, an in-depth overview is provided about the transport phenomena inmembrane oxygenators aiming to provide a better understanding of the molecular and process aspects of the process. An overview of the state of the art is summarized along with points about the trends of future developments are provided at the end.

Topics

• impedance spectroscopy
• microstructure
• laser emission spectroscopy
• biocompatibility