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Naji, M. |
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Motta, Antonella |
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Aletan, Dirar |
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Mohamed, Tarek |
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Ertürk, Emre |
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Taccardi, Nicola |
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Kononenko, Denys |
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Petrov, R. H. | Madrid |
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Alshaaer, Mazen | Brussels |
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Bih, L. |
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Casati, R. |
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Muller, Hermance |
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Kočí, Jan | Prague |
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Šuljagić, Marija |
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Kalteremidou, Kalliopi-Artemi | Brussels |
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Azam, Siraj |
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Ospanova, Alyiya |
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Blanpain, Bart |
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Ali, M. A. |
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Popa, V. |
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Rančić, M. |
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Ollier, Nadège |
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Azevedo, Nuno Monteiro |
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Landes, Michael |
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Rignanese, Gian-Marco |
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Singh, Saurabh
Institute of Science and Technology Austria
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (10/10 displayed)
- 2024In-situ engineered highly-crystalline Polythiophene empowered electrochemical capacitor-II: Anomalous electrochemical charge storage behavior of Polythiophene-rGO composite
- 2024In-situ engineered highly crystalline polythiophene empowered electrochemical capacitor-I: Synthesis, characterization, and electrochemical charge storagecitations
- 2024Polycrystalline phases engineered in-situ in polyaniline-graphene composite evoluting an exceptional stability and high charge storage capacity: An EIS investigative approach to evaluate material's stabilitycitations
- 2023Improvement of thermoelectric performance of flexible compound Ag2S0.55Se0.45 by means of partial V-substitution for Agcitations
- 2023Effect of the annealing treatment on structural and transport properties of thermoelectric Smy(FexNi1-x)4Sb12thin filmscitations
- 2023Lattice effects on the physical properties of half-doped perovskite ruthenatescitations
- 2022Electronic structure of silver chalcogenides investigated by hard x-ray photoemission spectroscopy and density functional theory calculationscitations
- 2022A reproducible dynamic phantom for sequence testing in hyperpolarised 13C-magnetic resonancecitations
- 2019Apparatus for Seebeck coefficient measurement of wire, thin film and bulk materials in the wide temperature range (80-650K)
- 2016Study of Tribological Behavior of Silicon Carbide Based Aluminum Metal Matrix Composites under Dry and Lubricated Environmentcitations
Places of action
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article
A reproducible dynamic phantom for sequence testing in hyperpolarised 13C-magnetic resonance
Abstract
<jats:sec><jats:title>Objective</jats:title><jats:p>To develop a phantom system which can be integrated with an automated injection system, eliminating the experimental variability that arises with manual injection; for the purposes of pulse sequence testing and metric derivation in hyperpolarised 13C-MR.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>The custom dynamic phantom was machined from Ultem and filled with a nicotinamide adenine dinucleotide and lactate dehydrogenase mixture dissolved in phosphate buffered saline. Hyperpolarised [1-13C]-pyruvate was then injected into the phantom (n = 8) via an automated syringe pump and the conversion of pyruvate to lactate monitored through a 13C imaging sequence.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>The phantom showed low coefficient of variation for the lactate to pyruvate peak signal heights (11.6%) and dynamic area-under curve ratios (11.0%). The variance for the lactate dehydrogenase enzyme rate constant (kP) was also seen to be low at 15.6%.</jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p>The dynamic phantom demonstrates high reproducibility for quantification of 13C-hyperpolarised MR-derived metrics. Establishing such a phantom is needed to facilitate development of hyperpolarsed 13C-MR pulse sequenced; and moreover, to enable multisite hyperpolarised 13C-MR clinical trials where assessment of metric variability across sites is critical.</jats:p></jats:sec><jats:sec><jats:title>Advances in knowledge</jats:title><jats:p>The dynamic phantom developed during the course of this study will be a useful tool in testing new pulse sequences and standardisation in future hyperpolarised work.</jats:p></jats:sec>