| People | Locations | Statistics |
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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Moreau, Philippe
Nantes Université
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (15/15 displayed)
- 2024Optimization of WLAM process Parameters for Metal Forming Tool Repair
- 20242D versus 3D‐Like Electrical Behavior of MXene Thin Films: Insights from Weak Localization in the Role of Thickness, Interflake Coupling and Defects
- 2023Impact of the metal centre (Al 3+ , Fe 3+ ) on the post-synthetic lithiation of functionalized MIL-53s and the electrochemical properties of lithiated derivativescitations
- 2022Pristine Surface of Ni-Rich Layered Transition Metal Oxides as a Premise of Surface Reactivitycitations
- 2022Application of a Cryo-FIB-SEM-μRaman Instrument to Probe the Depth of Vitreous Ice in a Frozen Samplecitations
- 2022Determination of the key structural factors affecting permeability and selectivity of PAN and PES polymeric filtration membranes using 3D FIB/SEMcitations
- 2020Friction Correction of Austenite Flow Stress Curves Determined under Axisymmetric Compression Conditionscitations
- 2020Genome-Wide Somatic Alterations in Multiple Myeloma Reveal a Superior Outcome Group.citations
- 2018Friction coefficients in cold forging: A global perspectivecitations
- 2016Fabrication and performance of electrochemically grafted thiophene silicon nanoparticle anodes for Li-ion batteriescitations
- 2016Nanoscale Chemical Evolution of Silicon Negative Electrodes Characterized by Low-Loss STEM-EELScitations
- 2015Engineered Electronic Contacts for Composite Electrodes in Li Batteries Using Thiophene-based Molecular Junctionscitations
- 2014Influence of swabbing compounds on loading, heat transfer and release performance in hot glass forming
- 2013Friction analysis at the glass/tool interface and the lubrication influence during hot forming cyclescitations
- 2013Deposition by radio frequency magnetron sputtering of GaV4S8 thin films for resistive random access memory applicationcitations
Places of action
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article
Genome-Wide Somatic Alterations in Multiple Myeloma Reveal a Superior Outcome Group.
Abstract
PURPOSE:Multiple myeloma (MM) is accompanied by heterogeneous somatic alterations. The overall goal of this study was to describe the genomic landscape of myeloma using deep whole-genome sequencing (WGS) and develop a model that identifies patients with long survival. METHODS:We analyzed deep WGS data from 183 newly diagnosed patients with MM treated with lenalidomide, bortezomib, and dexamethasone (RVD) alone or RVD + autologous stem cell transplant (ASCT) in the IFM/DFCI 2009 study (ClinicalTrials.gov identifier: NCT01191060). We integrated genomic markers with clinical data. RESULTS:We report significant variability in mutational load and processes within MM subgroups. The timeline of observed activation of mutational processes provides the basis for 2 distinct models of acquisition of mutational changes detected at the time of diagnosis of myeloma. Virtually all MM subgroups have activated DNA repair-associated signature as a prominent late mutational process, whereas APOBEC signature targeting C>G is activated in the intermediate phase of disease progression in high-risk MM. Importantly, we identify a genomically defined MM subgroup (17% of newly diagnosed patients) with low DNA damage (low genomic scar score with chromosome 9 gain) and a superior outcome (100% overall survival at 69 months), which was validated in a large independent cohort. This subgroup allowed us to distinguish patients with low- and high-risk hyperdiploid MM and identify patients with prolongation of progression-free survival. Genomic characteristics of this subgroup included lower mutational load with significant contribution from age-related mutations as well as frequent NRAS mutation. Surprisingly, their overall survival was independent of International Staging System and minimal residual disease status. CONCLUSION:This is a comprehensive study identifying genomic markers of a good-risk group with prolonged survival. Identification of this patient subgroup will affect future therapeutic algorithms and research planning.