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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Li, Jie
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (17/17 displayed)
- 2024Micromechanical and Tribological Performance of Laser-Cladded Equiatomic FeNiCr Coatings Reinforced with TiC and NbC Particlescitations
- 2024Adaptive Control of Melt Pressure in Polymer Extrusion Processes Using Extremum-Seeking Control
- 2024Adaptive Neuro-Fuzzy Controller for Real-Time Melt Pressure Control in Polymer Extrusion Processes
- 2023Improvement of Low Plasticity Clay with Crushed Glass: A Mechanical and Microstructural Studycitations
- 2023Nanostructured block copolymer single-ion conductors for low-temperature, high-voltage and fast charging lithium-metal batteriescitations
- 2023Melt Pressure Prediction in Polymer Extrusion Processes with Deep Learningcitations
- 2022Abstract WP257: RNS60 Provides Acute And Chronic Protection Of Brain Cells And Function In A Mouse Stroke Model
- 2022Abstract EP02: Identification Of Genetic Signals For “Diabesity” --- Type 2 Diabetes And Obesity -- Among African American And European American Participants In Four Cohorts Of The TOPMed Consortium
- 2021Shear strength and life cycle assessment of volcanic ash-based geopolymer and cement stabilized soilcitations
- 2020Temperature Window for Encapsulation of an Enzyme into Thermally Shrunk, CaCO3 Templated Polyelectrolyte Multilayer Capsules.citations
- 2020In-situ strength estimation of polypropylene fibre reinforced recycled aggregate concrete using Schmidt rebound hammer and point load testcitations
- 2020Temperature window for encapsulation of an enzyme into thermally shrunk, CaCO3 templated polyelectrolyte multilayer capsulescitations
- 2019Numerical investigation of polymer coated nanoporous goldcitations
- 2016Nanostructured ZnFe2O4 as Anode Material for Lithium Ion Batteries: Ionic Liquid-Assisted Synthesis and Performance Evaluation with Special Emphasis on Comparative Metal Dissolution
- 2015Multiscale structure characterization of sawdust-waste water sludge extrudates dried in a pilot-scale fixed bedcitations
- 2015Thermal, compositional, and compressional demagnetization of cementitecitations
- 2014Complementary and alternative medicine in reducing radiation-induced skin toxicity.citations
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article
Abstract WP257: RNS60 Provides Acute And Chronic Protection Of Brain Cells And Function In A Mouse Stroke Model
Abstract
<jats:p><jats:bold>Introduction:</jats:bold>RNS60 is an experimental treatment containing oxygen nanobubbles. RNS60 has previously been shown to reduce neuroinflammation and increase neuronal survival in animal models of multiple sclerosis, amyotrophic lateral sclerosis (ALS), Alzheimer's and Parkinson’s diseases, and traumatic brain injury. RNS60 is in phase 2 clinical testing as a treatment for ALS and acute ischemic stroke. Since RNS60 is protective in a variety of pathophysiological conditions that activate neurodegeneration, we evaluated whether RNS60 can reduce brain injury and rescue cognitive functions in a mouse model of ischemic stroke.</jats:p><jats:p><jats:bold>Methods:</jats:bold>Male C57BL/6J mice (4 months old) were subjected to transient (60 min) occlusion of the middle cerebral artery (tMCAo) followed by reperfusion, or sham surgery. We investigated the effects of post-stroke RNS60 treatment for 3 or 13 days (beginning 1 hour after reperfusion, 0.2 mL administered i.p., 1/day). Two control treatments (normal saline or oxygenated saline without nanobubbles) were used for comparison. Experimenters were blinded to the treatment groups throughout the study. To assess the post-stroke effects of RNS60 treatments, we performed multiple neurobehavioral tests that included modified neurological severity score (mNSS), novel object recognition (NOR), active place avoidance (APA), and the conflict variant of APA. Brains were collected for assessment of infarct volumes or for immunofluorescence measurements of amyloid, neurons, microglia, and axons.</jats:p><jats:p><jats:bold>Results:</jats:bold>Three days of treatment with RNS60 reduced brain infarction, edema, sensory-motor, and cognitive deficits. Thirteen days of treatment reduced brain infarction, amyloid pathology, neuronal cell death, microglial activation, and white matter damage. Noteworthy behavioral effects included recovery of memory during NOR and cognitive flexibility in the APA conflict variant.</jats:p><jats:p><jats:bold>Conclusion:</jats:bold>RNS60 treated mice exhibit significant acute and chronic protection of brain cells and neurobehavior after experimental stroke. Our data support the evaluation of RNS60 in clinical stroke trials.</jats:p>