| People | Locations | Statistics |
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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Mazurek, Piotr Stanislaw
Technical University of Denmark
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (27/27 displayed)
- 2023Antimicrobial silicone skin adhesives facilitated by controlled octenidine release from glycerol compartmentscitations
- 2022Multiscale characterisation of strains in semicrystalline polymers
- 2020Glycerol-silicone adhesives with excellent fluid handling and mechanical properties for advanced wound care applicationscitations
- 2019Glycerol-silicone foams - Tunable 3-phase elastomeric porous materialscitations
- 2019Silicone elastomer map: design the ideal elastomercitations
- 2019Hybrid Glycerol-Silicone Adhesives with Excellent Moisture Handling Properties for Advanced Wound Care Applications
- 2019Silicone elastomer map: Design the ideal elastomer
- 2019Design of reliable silicone elastomers for dielectric elastomers and stretchable electronicscitations
- 2019Designing reliable silicone elastomers for high temperature applications
- 2019Glycerol-silicone elastomers as active matrices with controllable release profiles
- 2019Advanced wound care adhesives with improved moisture handling capabilities
- 2019Development of Novel , Skin Friendly Glycerol Silicone Hybrid Adhesives
- 2018Designing reliable silicone elastomers for high-temperature applicationscitations
- 2018Advanced Wound Care Adhesives with New Functional Properties
- 2018Thermal degradation mechanisms of silicone elastomer
- 2018Silicone elastomers and their preparation and use
- 2018Insight into the Dielectric Breakdown of Elastomers
- 2018Glycerol-silicone elastomers – current status and perspectives
- 2018Glycerol-silicone elastomers as active membranes for wound dressings and beyond
- 2018Deeper Insight into the Dielectric Breakdown of Elastomers
- 2017Novel high dielectric constant hybrid elastomers as candidates for dielectric elastomer actuators
- 2016Glycerol as high-permittivity liquid filler in dielectric silicone elastomerscitations
- 2016A simple method for reducing inevitable dielectric loss in high-permittivity dielectric elastomerscitations
- 2016Novel high dielectric constant hybrid elastomers based on glycerol-insilicone emulsionscitations
- 2015Mechanically invisible encapsulations
- 2014Novel encapsulation technique for incorporation of high permittivity fillers into silicone elastomerscitations
- 2013Reinforced poly(propylene oxide)- a very soft and extensible dielectric electroactive polymercitations
Places of action
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article
Antimicrobial silicone skin adhesives facilitated by controlled octenidine release from glycerol compartments
Abstract
For improved wound healing, antimicrobial adhesives are one path forward. However, with the current challenge of bacterial resistance, it is essential to choose the included drug carefully. Octenidine is an obvious choice due to its broad antimicrobial efficacy and no reported bacterial resistance. In its pure form, octenidine complexes efficiently with the platinum catalyst in the silicone composition, inhibiting the targeted hydrosilylation reaction and hindering curing. This obstacle is overcome by screening octenidine with cyclodextrins in homogeneously dispersed glycerol droplets, suppressing Pt inhibition in the silicone phase. Curing efficiency is demonstrated using rheology, which shows that it is possible to incorporate one wt% of octenidine into glycerol–silicone adhesives in the presence of (2-hydroxypropyl)-β-cyclodextrin without affecting the adhesives’ mechanical properties. The interaction between octenidine and (2-hydroxypropyl)-β-cyclodextrin through an inclusion complex is confirmed by ROESY spectroscopy. Despite this screening, octenidine is still released efficiently from the glycerol–silicone adhesives upon contact with water, and the resulting antimicrobial action is subsequently demonstrated. This new technology constitutes a simple and efficient method for preparing wound care adhesives that actively inhibit the growth of four bacteria strains and one fungus.