| People | Locations | Statistics |
|---|---|---|
| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Grande, Daniel
Institut Charles Sadron
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (10/10 displayed)
- 2024Toward the Development of Graphene/Chitosan Biocomposite Aerogels with Enhanced Mechanical and Thermal Insulation Performancecitations
- 2024Antibiotic-loaded gelatin fibers fighting bacteria resistant to antibiotics: a case of spectinomycin-resistant Escherichia colicitations
- 2024Multiscale characterization of effective mechanical properties of graphene-chitosan composite aerogelscitations
- 2024Transition from Steric to Electrostatic Stabilization in Shell-Degradable Waterborne Particles Obtained by Photopolymerization-Induced Self-Assemblycitations
- 2023Effect of Amino-Functionalized Polyhedral Oligomeric Silsesquioxanes on Structure-Property Relationships of Thermostable Hybrid Cyanate Ester Resin Based Nanocompositescitations
- 2023Effect of Amino-Functionalized Polyhedral Oligomeric Silsesquioxanes on Structure-Property Relationships of Thermostable Hybrid Cyanate Ester Resin Based Nanocompositescitations
- 2023Diblock and Triblock Copolymers as Nanostructured Precursors to Functional Nanoporous Materials: From Design to Applicationcitations
- 2021Investigation of morphology associated with biporous polymeric materials obtained by the double porogen templating approachcitations
- 2015Annealing behavior and thermal stability of nanoporous polymer films based on high-performance Cyanate Ester Resinscitations
- 2005Cyanoxyl-mediated free-radical polymerization of acrylic acid: Its scope and limitationscitations
Places of action
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article
Antibiotic-loaded gelatin fibers fighting bacteria resistant to antibiotics: a case of spectinomycin-resistant Escherichia coli
Abstract
Infection with antibiotic-resistant bacteria can lead to higher mortality, morbidity, and healthcare costs. An open wound is highly susceptible to microbial infection. To encourage prompt healing, a wound requires a biomimetic dressing material, ideally with hydrophilic and antimicrobial properties. Herein, we propose hydrophobic, cargo-loaded gelatin fibers useable against antibiotic-resistant bacteria. Scanning electron microscopy (SEM) demonstrated the successful formation of the hydrophilic fibers and allowed us to characterize the morphology and the average fiber diameter before and after hydrophobic cargo loading. Differential scanning calorimetry (DSC) measurements indicated that the gelatin-based fibers may have undergone renaturation after electrospinning. Dynamic mechanical analysis (DMA) measurements showed that the presence of hydrophobic cargo enhanced the mechanical properties of the gelatin fibers without the necessity of a crosslinking step. The measurements were then repeated for the fiber when loaded with ciprofloxacin, a hydrophobic antibiotic. The in vitro antibacterial property of the designed ciprofloxacin-loaded gelatin fibers was evaluated by film-diffusion against spectinomycin-resistant Escherichia coli. An inhibitory effect on bacterial growth in a solid medium was observed. These findings demonstrated the potential of the designed fiber to be used as an antimicrobial material for the prevention and treatment of wound infections, particularly those resistant to antibiotic therapy.