| People | Locations | Statistics |
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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Urquhart, Andrew J.
Technical University of Denmark
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (12/12 displayed)
- 2022Reactive Oxygen Species-Responsive Polymer Nanoparticles to Improve the Treatment of Inflammatory Skin Diseasescitations
- 2019Pressure-induced polymorphism of caprolactam: A neutron diffraction studycitations
- 2017Compression of glycolide-h4 to 6GPacitations
- 2017Compression of glycolide-h 4 to 6GPacitations
- 2015Polymorphism of a polymer precursor: metastable glycolide polymorph recovered via large scale high-pressure experimentscitations
- 2012Polymer templating of supercooled indomethacin for polymorph selectioncitations
- 2012Inclusion of water insoluble drugs in amorphous silica nanoparticlescitations
- 2011ToF-SIMS Analysis of Dexamethasone Distribution in the Isolated Perfused Eyecitations
- 2011Polymorphism and polymerisation of acrylic and methacrylic acid at high pressurecitations
- 2011ToF-SIMS analysis of ocular tissues reveals biochemical differentiation and drug distributioncitations
- 2009Partial least squares regression as a powerful tool for investigating large combinatorial polymer librariescitations
- 2008TOF-SIMS analysis of a 576 micropatterned copolymer array to reveal surface moieties that control wettabilitycitations
Places of action
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article
Reactive Oxygen Species-Responsive Polymer Nanoparticles to Improve the Treatment of Inflammatory Skin Diseases
Abstract
To improve the quality of life for people living with chronic inflammatory skin diseases, we propose a new treatment strategy by exploring a stimuli-responsive drug delivery system. Formulations designed by exploiting smart materials can be programmed to perform a specific action upon exposure to disease-related stimuli. For instance, increased levels of reactive oxygen species (ROS), especially the accumulation of hydrogen peroxide, can be utilized to differentiate between healthy and inflamed tissues. In this concept-proofing study, the polymer poly(1,4 phenyleneacetone dimethylene thioketal) (PPADT) was investigated for its ROS-responsive properties and potential to treat inflammatory skin diseases. PPADT nanoparticles were formulated by oil-in-water emulsification followed by solvent evaporation and characterized by size, zeta-potential, and release kinetic profiles. Release profiles revealed that the PPADT nanoparticles were sensitive toward elevated levels of ROS in an ROS-stimulus concentration (0.1-10 mM) and time-dependent manner (flare-up mimicked). The safety assessment proved that the PPADT polymer and the monomers generated by oxidation do not show any sign of being cytotoxic to fibroblasts and no mutagenic liabilities were observed. In conclusion, the PPADT polymer demonstrated to be a promising material for stimuli-responsive delivery of hydrophobic small molecules in the treatment of inflammatory skin diseases.