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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Robertson, John
University of Strathclyde
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (21/21 displayed)
- 2022Halide Perovskites: Advanced Photovoltaic Materials Empowered by a Unique Bonding Mechanismcitations
- 2022Printability of pharmaceutical Fused Deposition Modeling (FDM) feedstock material
- 2021Halide Perovskites: Advanced Photovoltaic Materials Empowered by a Unique Bonding Mechanism
- 2019Use of terahertz-Raman spectroscopy to determine solubility of the crystalline active pharmaceutical ingredient in polymeric matrices during hot melt extrusioncitations
- 2018Carbon nanotube isolation layer enhancing in-liquid quality-factors of thin film bulk acoustic wave resonators for gravimetric sensing
- 2018Insulator-to-Metallic Spin-Filtering in 2D-Magnetic Tunnel Junctions Based on Hexagonal Boron Nitridecitations
- 2017Defect passivation of transition metal dichalcogenides via a charge transfer van der Waals interface.
- 2017Low temperature growth of fully covered single-layer graphene using a CoCu catalystcitations
- 2017Low temperature growth of fully covered single-layer graphene using a CoCu catalyst.
- 2016Modelling of co-rotating twin-screw extruders in the pharmaceutical industry I
- 2015High-K materials and metal gates for CMOS applications
- 2015Spatial variability in large area single and few-layer CVD graphene
- 2015Influence of packing density and surface roughness of vertically-aligned carbon nanotubes on adhesive properties of gecko-inspired mimetics.
- 2014Bio-inspired hierarchical polymer fiber-carbon nanotube adhesivescitations
- 2014The role of the sp2:sp3 substrate content in carbon supported nanotube growthcitations
- 2014The role of the sp 2 :sp 3 substrate content in carbon supported nanotube growthcitations
- 2012The phase of iron catalyst nanoparticles during carbon nanotube growthcitations
- 2007Diamond-like carbon for data and beer storagecitations
- 2006Periodic inclusion of room-temperature-ferromagnetic metal phosphide nanoparticles in carbon nanotubescitations
- 2005Materials science: The ultrasmoothness of diamond-like carbon surfacescitations
- 2004Hydrogen content estimation of hydrogenated amorphous carbon by visible Raman spectroscopycitations
Places of action
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article
Use of terahertz-Raman spectroscopy to determine solubility of the crystalline active pharmaceutical ingredient in polymeric matrices during hot melt extrusion
Abstract
<p>Polymer-based amorphous solid dispersions (ASDs) comprise one of the most promising formulation strategies devised to improve the oral bioavailability of poorly water-soluble drugs. Exploitation of such systems in marketed products has been limited because of poor understanding of physical stability. The internal disordered structure and increased free energy provide a thermodynamic driving force for phase separation and recrystallization, which can compromise therapeutic efficacy and limit product shelf life. A primary concern in the development of stable ASDs is the solubility of the drug in the polymeric carrier, but there is a scarcity of reliable analytical techniques for its determination. In this work, terahertz (THz) Raman spectroscopy was introduced as a novel empirical approach to determine the saturated solubility of crystalline active pharmaceutical ingredient (API) in polymeric matrices directly during hot melt extrusion. The solubility of a model compound, paracetamol, in two polymer systems, Affinisol 15LV (HPMC) and Plasdone S630 (copovidone), was determined by monitoring the API structural phase transitions from crystalline to amorphous as an excess of crystalline drug dissolved in the polymeric matrix. THz-Raman results enabled construction of solubility phase diagrams and highlighted significant differences in the solubilization capacity of the two polymer systems. The maximum stable API-load was 20 wt % for Affinisol 15LV and 40 wt % for Plasdone S630. Differential scanning calorimetry and XRPD studies corroborated these results. This approach has demonstrated a novel capability to provide real-time API-polymer phase equilibria data in a manufacturing relevant environment and promising potential to predict solid-state solubility and physical stability of ASDs.</p>