| People | Locations | Statistics |
|---|---|---|
| Naji, M. |
| |
| Motta, Antonella |
| |
| Aletan, Dirar |
| |
| Mohamed, Tarek |
| |
| Ertürk, Emre |
| |
| Taccardi, Nicola |
| |
| Kononenko, Denys |
| |
| Petrov, R. H. | Madrid |
|
| Alshaaer, Mazen | Brussels |
|
| Bih, L. |
| |
| Casati, R. |
| |
| Muller, Hermance |
| |
| Kočí, Jan | Prague |
|
| Šuljagić, Marija |
| |
| Kalteremidou, Kalliopi-Artemi | Brussels |
|
| Azam, Siraj |
| |
| Ospanova, Alyiya |
| |
| Blanpain, Bart |
| |
| Ali, M. A. |
| |
| Popa, V. |
| |
| Rančić, M. |
| |
| Ollier, Nadège |
| |
| Azevedo, Nuno Monteiro |
| |
| Landes, Michael |
| |
| Rignanese, Gian-Marco |
|
Weidner, Tobias
Aarhus University
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (29/29 displayed)
- 2022Peptide Orientation at Emulsion Nanointerfaces Dramatically Different from Flat Surfacescitations
- 2021Windowless detection geometry for sum frequency scattering spectroscopy in the C-D and amide i regionscitations
- 2021Insects use lubricants to minimize friction and wear in leg jointscitations
- 2020Role of Surface Chemistry in the Superhydrophobicity of the Springtail Orchesella cincta (Insecta:Collembola)citations
- 2020Lasalocid Acid Antibiotic at a Membrane Surface Probed by Sum Frequency Generation Spectroscopycitations
- 2018Structure of von Willebrand factor A1 on polystyrene determined from experimental and calculated sum frequency generation spectracitations
- 2018The surface chemistry of iron oxide nanocrystalscitations
- 2018Effect of Internal Heteroatoms on Level Alignment at Metal/Molecular Monolayer/Si Interfacescitations
- 2016Kinetically Controlled Sequential Growth of Surface-Grafted Chiral Supramolecular Copolymerscitations
- 2016Differential surface activation of the A1 domain of von Willebrand factorcitations
- 2016Functionalization of nanocrystalline diamond films with phthalocyaninescitations
- 2015Multiscale Effects of Interfacial Polymer Confinement in Silica Nanocompositescitations
- 2013Effects of self-assembled monolayer structural order, surface homogeneity and surface energy on pentacene morphology and thin film transistor device performancecitations
- 2013SFG analysis of surface bound proteinscitations
- 2013Covalently attached organic monolayers onto silicon carbide from 1-alkynescitations
- 2013Molecular suction padscitations
- 2012Probing the orientation of electrostatically immobilized protein G B1 by time-of-flight secondary ion spectrometry, sum frequency generation, and near-edge X-ray adsorption fine structure spectroscopycitations
- 2012Zwitterionic dithiocarboxylates derived from N-heterocyclic carbenescitations
- 2012Bottom-contact small-molecule n-type organic field effect transistors achieved via simultaneous modification of electrode and dielectric surfacescitations
- 2012Solid-state densification of spun-cast self-assembled monolayers for use in ultra-thin hybrid dielectricscitations
- 2011Simultaneous modification of bottom-contact electrode and dielectric surfaces for organic thin-film transistors through single-component spin-cast monolayerscitations
- 2011Probing albumin adsorption onto calcium phosphates by x-ray photoelectron spectroscopy and time-of-flight secondary ion mass spectrometrycitations
- 2011Characterization of poly(sodium styrene sulfonate) thin films grafted from functionalized titanium surfacescitations
- 2010Probing the orientation of surface-immobilized protein G B1 using ToF-SIMS, sum frequency generation, and NEXAFS spectroscopycitations
- 2010Multi-technique Characterization of Adsorbed Peptide and Protein Orientationcitations
- 2010Structure and Order of Phosphonic Acid-Based Self-Assembled Monolayers on Si(100)citations
- 2010Effect of the phenyl ring orientation in the polystyrene buffer layer on the performance of pentacene thin-film transistorscitations
- 2009Self-Assembly of a Pyridine-Terminated Thiol Monolayer on Au(111)citations
- 2009Amide or Aminecitations
Places of action
| Organizations | Location | People |
|---|
article
Lasalocid Acid Antibiotic at a Membrane Surface Probed by Sum Frequency Generation Spectroscopy
Abstract
Carboxyl polyether ionophores (CPIs) are widely used as veterinary antibiotics and to increase food utilization in ruminating animals. Furthermore, CPIs can target drug-resistant bacteria, but detailed knowledge about their mode-of-action is needed to develop agents with a reasonable therapeutic index. It has been suggested that ionophores bind to membranes and incur large structural changes to shield a bound ion from the hydrophobic environment of the lipid bilayer for transport. One crucial piece of information is missing, however: Is it necessary for the free ionophore to adsorb on the membrane surface before interacting with a cation to facilitate cross-membrane ion transport? To answer this question, we applied sum-frequency generation (SFG) vibrational spectroscopy and surface tensiometry to identify the interaction between the prototypical CPI lasalocid acid (LA) and a model membrane. Observed changes in the surface pressure demonstrate that the free LA undergoes a self-assembly process with the lipid monolayer. Spectra taken from the lipid monolayer show that the free acid inserts partially into the lipid monolayer and then after complexation with sodium chloride disrupts the lipid monolayer. Overall, this study strongly suggests that this must be the crucial step of LA and metal ion complexation that allows the ionophore to traverse a lipid membrane.