| People | Locations | Statistics |
|---|---|---|
| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Rottmar, Markus
Swiss Federal Laboratories for Materials Science and Technology
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (12/12 displayed)
- 2024Amino-acid-specific thiol-ene coupling governs hydrogel crosslinking mechanism and cell behaviorcitations
- 20233D-printed poly(3-hydroxybutyrate-co-3-hydroxyhexanoate)-cellulose-based scaffolds for biomedical applicationscitations
- 20233D-Printed Poly(3-hydroxybutyrate-co-3-hydroxyhexanoate)-Cellulose-Based Scaffolds for Biomedical Applicationscitations
- 2023Surface chemistry dictates the osteogenic and antimicrobial properties of palladium-, platinum-, and titanium-based bulk metallic glassescitations
- 2022Multiscale 2D/3D microshaping and property tuning of polymer-derived SiCN ceramicscitations
- 2022Palladium-based metallic glass with high thrombogenic resistance for blood-contacting medical devicescitations
- 2021Nano‐3D‐printed photochromic micro‐objectscitations
- 2020In vitro cytocompatibility assessment of Ti-modified silicon-oxycarbide based polymer-derived ceramic implantable electrodes under pacing conditionscitations
- 2020Responsive Nanofibers with Embedded Hierarchical Lipid Self-Assembliescitations
- 2019Mussel-inspired injectable hydrogel adhesive formed under mild conditions features near-native tissue propertiescitations
- 2018Controlling the surface structure of electrospun fibers: effect on endothelial cells and blood coagulationcitations
- 2016A bioinspired ultraporous nanofiber-hydrogel mimic of the cartilage extracellular matrixcitations
Places of action
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article
Responsive Nanofibers with Embedded Hierarchical Lipid Self-Assemblies
Abstract
We introduce the design and study of a hybrid electrospun membrane with a dedicated nanoscale structural hierarchy for controlled functions in the biomedical domain. The hybrid system comprises submicrometer-sized internally self-assembled lipid nanoparticles (ISAsomes or mesosomes) embedded into the electrospun membrane with a nanofibrous polymer network. The internal structure of ISAsomes, studied by small-angle X-ray scattering (SAXS) and electron microscopy, demonstrated a spontaneous response to variations in the environmental conditions as they undergo a bicontinuous inverse cubic phase (cubosomes) in solution to a crystalline lamellar phase in the polymer membrane; nevertheless, this phase reorganization is reversible. As revealed by in situ SAXS measurements, if the membrane was put in contact with aqueous media, the cubic phase reappeared and submicrometer-sized cubosomes were released upon dissolution of the nanofibers. Furthermore, the hybrid membranes exhibited a specific anisotropic feature and morphological response under an external strain. While nanofibers were aligned under external strain in the microscale, the semicrystalline domains from the polymer phase were positioned perpendicular to the lamellae of the lipid phase in the nanoscale. The fabricated membranes and their spontaneous responses offer new strategies for the development of structure-controlled functions in electrospun nanofibers for biomedical applications, such as drug delivery or controlled interactions with biointerfaces.