| People | Locations | Statistics |
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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Rantanen, Jukka
University of Copenhagen
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (43/43 displayed)
- 2024Leucine as a Moisture-Protective Excipient in Spray-Dried Protein/Trehalose Formulationcitations
- 2024Compaction behavior of freeze-dried and spray-dried trypsin/lactose particulate systems
- 2023Co-administration of Intravenous Drugscitations
- 2023Coating of Primary Powder Particles Improves the Quality of Binder Jetting 3D Printed Oral Solid Productscitations
- 2022Structured approach for designing drug-loaded solid products by binder jetting 3D printingcitations
- 2021Enabling formulations of aprepitantcitations
- 2020Fabrication of Mucoadhesive Buccal Films for Local Administration of Ketoprofen and Lidocaine Hydrochloride by Combining Fused Deposition Modeling and Inkjet Printingcitations
- 2020Exploring the Complexity of Processing-Induced Dehydration during Hot Melt Extrusion Using In-Line Raman Spectroscopycitations
- 2019Determining Thermal Conductivity of Small Molecule Amorphous Drugs with Modulated Differential Scanning Calorimetry and Vacuum Molding Sample Preparationcitations
- 2019Exploring the chemical space for freeze-drying excipientscitations
- 2019Roadmap to 3D printed oral pharmaceutical dosage formscitations
- 2018The use of molecular descriptors in the development of co-amorphous formulationscitations
- 2017Investigation of nanocarriers and excipients for preparation of nanoembedded microparticlescitations
- 2017Correlation between calculated molecular descriptors of excipient amino acids and experimentally observed thermal stability of lysozymecitations
- 2017The flow properties and presence of crystals in drug-polymer mixturescitations
- 2017The effect of poly (lactic-co-glycolic) acid composition on the mechanical properties of electrospun fibrous matscitations
- 2017The effect of poly (lactic-co-glycolic) acid composition on the mechanical properties of electrospun fibrous matscitations
- 2016Oscillatory Shear Rheology in Examining the Drug-Polymer Interactions Relevant in Hot Melt Extrusioncitations
- 2016Properties of the Sodium Naproxen-Lactose-Tetrahydrate Co-Crystal upon Processing and Storagecitations
- 2015Three-Dimensional Printing of Drug-Eluting Implantscitations
- 2015Well-plate freeze-dryingcitations
- 2015Rheology as a tool for evaluation of melt processability of innovative dosage formscitations
- 2014Evaluation of ring shear testing as a characterization method for powder flow in small-scale powder processing equipmentcitations
- 2014Near-Infrared Imaging for High-Throughput Screening of Moisture-Induced Changes in Freeze-Dried Formulationscitations
- 2013A step toward development of printable dosage forms for poorly soluble drugscitations
- 2013Interpreting the Disordered Crystal Structure of Sodium Naproxen Tetrahydratecitations
- 2013Designing CAF-adjuvanted dry powder vaccinescitations
- 2013Investigation of the phase separation of PNIPAM using infrared spectroscopy together with multivariate data analysiscitations
- 2013Fast-track to a solid dispersion formulation using multi-way analysis of complex interactionscitations
- 2013Foreign matter identification from solid dosage formscitations
- 2013Exploring the solid-form landscape of pharmaceutical hydratescitations
- 2012Complementing high-throughput X-ray powder diffraction data with quantum-chemical calculationscitations
- 2012Crystal morphology modification by the addition of tailor-made stereocontrolled poly(N-isopropyl acrylamide)citations
- 2012Atomic pairwise distribution function analysis of the amorphous phase prepared by different manufacturing routescitations
- 2011Assessment of crystalline disorder in cryo-milled samples of indomethacin using atomic pair-wise distribution functionscitations
- 2006Understanding processing-induced phase transformations in erythromycin-PEG 6000 solid dispersionscitations
- 2005Physical changes of beta-sitosterol crystals in oily suspensions during heatingcitations
- 2005IR spectroscopy together with multivariate data analysis as a process analytical tool for in-line monitoring of crystallization process and solid-state analysis of crystalline productcitations
- 2005Pellet manufacturing by extrusion-spheronization using process analytical technologycitations
- 2005Characterization of polymorphic solid-state changes using variable temperature X-ray powder diffractioncitations
- 2004Role of excipients in hydrate formation kinetics of theophylline in wet masses studied by near-infrared spectroscopycitations
- 2003Dehydration studies using a novel multichamber microscale fluid bed dryer with in-line near-infrared measurementcitations
- 2002Hydrate formation during wet granulation studied by spectroscopic methods and multivariate analysis
Places of action
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article
Roadmap to 3D printed oral pharmaceutical dosage forms
Abstract
<p>Application of additive manufacturing techniques (3D printing) for mass-customized products has boomed in the recent years. In pharmaceutical industry and research, the interest has grown particularly with the future scenario of more personalized medicinal products. Understanding a broad range of material properties and process behavior of the drug-excipient combinations is necessary for successful 3D printing of dosage forms. This commentary reviews recent 3D printing studies by fused deposition modeling (FDM) technique in pharmaceutical sciences, extending into the fields of polymer processing and rapid prototyping, where more in-depth studies on the feedstock material properties, modeling and simulation of the FDM process have been performed. A case study of a model oral dosage form from custom-prepared indomethacin-polycaprolactone feedstock filament was used as an example in the pharmaceutical context. The printability was assessed in the different process steps: preparation of customized filaments for FDM, filament feeding, deposition, and solidification. These were linked with the rheological, thermal, and mechanical properties and their characterization, relevant for understanding the printability of drug products by FDM.</p>