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Naji, M. |
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Motta, Antonella |
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Aletan, Dirar |
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Mohamed, Tarek |
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Ertürk, Emre |
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Taccardi, Nicola |
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Kononenko, Denys |
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Petrov, R. H. | Madrid |
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Alshaaer, Mazen | Brussels |
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Bih, L. |
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Casati, R. |
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Muller, Hermance |
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Kočí, Jan | Prague |
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Šuljagić, Marija |
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Kalteremidou, Kalliopi-Artemi | Brussels |
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Azam, Siraj |
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Ospanova, Alyiya |
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Blanpain, Bart |
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Ali, M. A. |
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Popa, V. |
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Rančić, M. |
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Ollier, Nadège |
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Azevedo, Nuno Monteiro |
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Landes, Michael |
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Rignanese, Gian-Marco |
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Wagner, S.
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (19/19 displayed)
- 2022Transformation Kinetics of LiBH4–MgH2 for Hydrogen Storagecitations
- 2019Estimation of swelling stresses from crack-terminating angles
- 2019The influence of weld imperfections on fatigue strength and the current relevant design guidelines
- 2018Influence of machining-induced martensite on hydrogen-assisted fracture of AISI type 304 austenitic stainless steelcitations
- 2018SIMS analysis on austenitic stainless steel: The influence of type of oxide surface layer on hydrogen embrittlementcitations
- 2018Very small superparamagnetic iron oxide nanoparticles: Long-term fate and metabolic processing in atherosclerotic mice.citations
- 2018SIMS study on the surface chemistry of stainless steel AISI 304 cylindrical tensile test samples showing hydrogen embrittlementcitations
- 2015Feasibility of the development of reference materials for the detection of Ag nanoparticles in food: neat dispersions and spiked chicken meatcitations
- 2013SIMS analysis on austenitic stainless steelcitations
- 2013SIMS analysis on austenitic stainless steel : The influence of type of oxide surface layer on hydrogen embrittlement
- 2013Synthetic routes to magnetic nanoparticles for MPI.citations
- 2011Investigation in development of embroidered strain measurement sensors
- 2011Finite element analysis of a crack tip in silicate glass : No evidence for a plastic zonecitations
- 2010Cyclic behavior and microstructural stability of ultrafine-grained AA6060 under strain-controlled fatiguecitations
- 2008Effect of temperature on grain size, phase composition, and electrical properties in the relaxor-ferroelectric-system Pb(Ni1/3Nb2/3)O-3-Pb(Zr,Ti)O-3
- 2004Phase I clinical evaluation of citrate-coated monocrystalline very small superparamagnetic iron oxide particles as a new contrast medium for magnetic resonance imaging.
- 2003Microfluidic actuation by modulation of surface stressescitations
- 2000Selective dip-coating of chemically micropatterned surfacescitations
- 2000Direct wet printing of polumer solutions for high resolution lithography
Places of action
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article
Very small superparamagnetic iron oxide nanoparticles: Long-term fate and metabolic processing in atherosclerotic mice.
Abstract
We investigated the biotransformation of very small superparamagnetic iron oxide nanoparticles (VSOP) in atherosclerotic LDLR-/- mice. Transmission electron microscopy revealed an uptake of VSOP not only by macrophages but also by endothelial cells in liver, spleen, and atherosclerotic lesions and their accumulation in the lysosomal compartment. Using magnetic particle spectroscopy (MPS), we show that the majority of VSOP's superparamagnetic iron was degraded within 28 days. MPS spectrum shape indicated changes in the magnetic properties of VSOP during the biodegradation process. Experiments with primary murine bone marrow derived macrophages, primary murine liver sinusoidal endothelial cells, and primary human aortic endothelial cells demonstrated that loading with VSOP induced a differential response of cellular iron homeostasis mechanisms with increased levels of ferritin and iron transport proteins in macrophages and increased levels of ferritin in endothelial cells.