| People | Locations | Statistics |
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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Bunea, Ada-Ioana
Technical University of Denmark
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (8/8 displayed)
- 20223D printed microrobots controlled by light – Towards environmental and biomedical applications
- 2021Micro 3D Printing by Two-Photon Polymerization: Configurations and Parameters for the Nanoscribe Systemcitations
- 2021Bioinspired microstructured polymer surfaces with antireflective propertiescitations
- 2021Additive manufacturing of polymeric scaffolds for biomimetic cell membrane engineeringcitations
- 2019Optimization of 3D-printed microstructures for investigating the properties of the mucus biobarriercitations
- 2018Light Robotics for Nanomedicine
- 2018Light Robotics – a growing toolbox for biomedical research
- 2018Optically fabricated and controlled microtool as a mobile heat source in microfluidics
Places of action
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article
Optimization of 3D-printed microstructures for investigating the properties of the mucus biobarrier
Abstract
In order to overcome the mucus biobarrier for drug delivery purposes, a better understanding of the interactions between mucus and the drug carrier is needed. We propose optical catapulting of 3D-printed microstructures with tailored shape and surface chemistry as a means to study the interaction filtering properties of a model mucus biobarrier in dynamic conditions. Using twophoton polymerization, we fabricate microstructures with a resolution of approximately 200 nm. We introduce amino functional groups on the surface of the IP-L 780-derived polymer in a single step process via UV-assisted functionalization with an anthraquinone amine photolinker. Our optical catapulting system relies on Generalized Phase Contrast for beam shaping and it allows us to manipulate microstructures over a distance of 250 µm, similar to the mucus layer thickness in the upper part of the lower human intestine. This work is part of an ongoing endeavor to establish Light Robotics as a valuable toolbox for biomedical research.