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Naji, M. |
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Motta, Antonella |
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Aletan, Dirar |
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Mohamed, Tarek |
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Ertürk, Emre |
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Taccardi, Nicola |
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Kononenko, Denys |
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Petrov, R. H. | Madrid |
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Alshaaer, Mazen | Brussels |
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Bih, L. |
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Casati, R. |
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Muller, Hermance |
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Kočí, Jan | Prague |
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Šuljagić, Marija |
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Kalteremidou, Kalliopi-Artemi | Brussels |
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Azam, Siraj |
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Ospanova, Alyiya |
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Blanpain, Bart |
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Ali, M. A. |
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Popa, V. |
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Rančić, M. |
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Ollier, Nadège |
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Azevedo, Nuno Monteiro |
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Landes, Michael |
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Rignanese, Gian-Marco |
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Sack, I.
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (23/23 displayed)
- 2024On the relationship between viscoelasticity and water diffusion in soft biological tissues.citations
- 2022Mechanical behavior of the hippocampus and corpus callosum: An attempt to reconcile ex vivo with in vivo and micro with macro properties.citations
- 2021Real-Time Multifrequency MR Elastography of the Human Brain Reveals Rapid Changes in Viscoelasticity in Response to the Valsalva Maneuver.citations
- 2020Cardiac-gated steady-state multifrequency magnetic resonance elastography of the brain: Effect of cerebral arterial pulsation on brain viscoelasticity.citations
- 2019Sensitivity of multifrequency magnetic resonance elastography and diffusion-weighted imaging to cellular and stromal integrity of liver tissue.citations
- 2018Combining viscoelasticity, diffusivity and volume of the hippocampus for the diagnosis of Alzheimer's disease based on magnetic resonance imaging.citations
- 2015Tabletop magnetic resonance elastography for the measurement of viscoelastic parameters of small tissue samples.citations
- 2014High-resolution mechanical imaging of the kidney.citations
- 2014Wideband MRE and static mechanical indentation of human liver specimen: sensitivity of viscoelastic constants to the alteration of tissue structure in hepatic fibrosis.citations
- 2014In vivo time-harmonic multifrequency elastography of the human liver.citations
- 2013Compression-sensitive magnetic resonance elastography.citations
- 2013Isovolumetric elasticity alteration in the human heart detected by in vivo time-harmonic elastography.citations
- 2012Fractal network dimension and viscoelastic powerlaw behavior: I. A modeling approach based on a coarse-graining procedure combined with shear oscillatory rheometry.citations
- 2010Viscoelasticity-based MR elastography of skeletal muscle.citations
- 2010Viscoelasticity-based staging of hepatic fibrosis with multifrequency MR elastography.citations
- 2010Viscoelastic properties of liver measured by oscillatory rheometry and multifrequency magnetic resonance elastography.citations
- 2008Non-invasive measurement of brain viscoelasticity using magnetic resonance elastography.citations
- 2008Assessment of liver viscoelasticity using multifrequency MR elastography.citations
- 2007Three-dimensional analysis of shear wave propagation observed by in vivo magnetic resonance elastography of the brain.citations
- 2007Noninvasive assessment of the rheological behavior of human organs using multifrequency MR elastography: a study of brain and liver viscoelasticity.citations
- 2006Shear wave group velocity inversion in MR elastography of human skeletal muscle.citations
- 2003Electromagnetic actuator for generating variably oriented shear waves in MR elastography.citations
- 2002Analysis of wave patterns in MR elastography of skeletal muscle using coupled harmonic oscillator simulations.
Places of action
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article
Sensitivity of multifrequency magnetic resonance elastography and diffusion-weighted imaging to cellular and stromal integrity of liver tissue.
Abstract
Microscopic structural alterations of liver tissue induced by freeze-thaw cycles give rise to palpable property changes. However, the underlying damage to tissue architecture is difficult to quantify histologically, and published data on macroscopic changes in biophysical properties are sparse. To better understand the influence of hepatic cells and stroma on global biophysical parameters, we studied rat liver specimens freshly taken (within 30 min after death) and treated by freeze-thaw cycles overnight at either -20 °C or -80 °C using diffusion-weighted imaging (DWI) and multifrequency magnetic resonance elastography (MRE) performed at 0.5 T in a tabletop MRE scanner. Tissue structure was analyzed histologically and rheologic data were analyzed using fractional order derivatives conceptualized by a called spring-pot component that interpolates between pure elastic and viscous responses. Overnight freezing and thawing induced membrane disruptions and cell detachment in the space of Disse, resulting in a markedly lower shear modulus μ and apparent diffusion coefficient (ADC) (μ[-20 °C] = 1.23 ± 0.73 kPa, μ[-80 °C] = 0.66 ± 0.75 kPa; ADC[-20 °C] = 0.649 ± 0.028 μm2 /s, ADC[-80 °C] = 0.626 ± 0.025 μm2 /s) compared to normal tissue (μ = 9.92 ± 3.30 kPa, ADC = 0.770 ± 0.023 μm2 /s, all p < 0.001). Furthermore, we analyzed the springpot-powerlaw coefficient and observed a reduction in -20 °C specimens (0.22 ± 0.14) compared to native tissue (0.40 ± 0.10, p = 0.033) and -80 °C specimens (0.54 ± 0.22, p = 0.002), that correlated with histological observations of sinusoidal dilation and collagen distortion within the space of Disse. Overall, the results suggest that shear modulus and water diffusion in liver tissue markedly decrease due to cell membrane degradation and cell detachment while viscosity-related properties appear to be more sensitive to distorted stromal and microvascular architecture.