| People | Locations | Statistics |
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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Markl, Daniel
University of Strathclyde
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (12/12 displayed)
- 2022Polymer pellet fabrication for accurate THz-TDS measurementscitations
- 2022Analysis of THz scattering of compacted granular materials using THz-TDScitations
- 2021Terahertz pulsed imaging as a new method for investigating the liquid transport kinetics of α-alumina powder compactscitations
- 2021Development of 3D printed rapid tooling for micro-injection mouldingcitations
- 2020Development and Validation of an in-line API Quantification Method Using AQbD Principles Based on UV-Vis Spectroscopy to Monitor and Optimise Continuous Hot Melt Extrusion Processcitations
- 2019Hot-melt extrusion process impact on polymer choice of glyburide solid dispersionscitations
- 2018Pharmaceutical-grade oral films as substrates for printed medicinecitations
- 2017On the role of API in determining porosity, pore structure and bulk modulus of the skeletal material in pharmaceutical tablets formed with MCC as sole excipientcitations
- 2017Optics-based compressibility parameter for pharmaceutical tablets obtained with the aid of the terahertz refractive indexcitations
- 2016Multi-methodological investigation of the variability of the microstructure of HPMC hard capsulescitations
- 2013Hot melt extrusion as a continuous pharmaceutical manufacturing processcitations
- 2013Supervisory control system for monitoring a pharmaceutical hot melt extrusion processcitations
Places of action
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article
Optics-based compressibility parameter for pharmaceutical tablets obtained with the aid of the terahertz refractive index
Abstract
The objective of this study is to propose a novel optical compressibility parameter for porous pharmaceutical tablets. This parameter is defined with the aid of the effective refractive index of a tablet that is obtained from non-destructive and contactless terahertz (THz) time-delay transmission measurement. The optical compressibility parameter of two training sets of pharmaceutical tablets with ${a priori}$ known porosity and mass fraction of a drug was investigated. Both pharmaceutical sets were compressed with one of the most commonly used excipients, namely microcrystalline cellulose (MCC) and drug Indomethacin. The optical compressibility clearly correlates with the skeletal bulk modulus determined by mercury porosimetry and the recently proposed terahertz lumped structural parameter calculated from terahertz measurements. This lumped structural parameter can be used to analyse the pattern of arrangement of excipient and drug particles in porous pharmaceutical tablets. Therefore, we propose that the optical compressibility can serve as a quality parameter of a pharmaceutical tablet corresponding with the skeletal bulk modulus of the porous tablet, which is related to structural arrangement of the powder particles in the tablet.