| People | Locations | Statistics |
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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Lyons, Sean
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (36/36 displayed)
- 2024Response Surface Modelling Nafion-117 Sorption of Tetraammineplatinum(II) Chloride in the Electroless Plating of IPMCscitations
- 2021Stereolithography (SLA) utilised to print injection mould tooling in order to evaluate thermal and mechanical properties of commercial polypropylenecitations
- 2020Fused filament fabrication of peekcitations
- 2020Effect of electron beam irradiation on the rheological properties and phase transition temperature of poly(N-vinylcaprolactam)
- 2019Comparison of fused-filament fabrication to direct compression and injection molding in the manufacture of oral tabletscitations
- 2019Additive manufacturing of PLA/HNT nanocomposites for biomedical applicationscitations
- 2019Stability studies of hot-melt extruded ternary solid dispersions of poorly-water soluble indomethacin with poly(vinyl pyrrolidone-co-vinyl acetate)and polyethylene oxidecitations
- 2019Processing of nanocomposites using supercritical fluid assisted extrusion for stress/strain sensing applicationscitations
- 2019Influence of annealing and biaxial expansion on the properties of poly(l-lactic acid) medical tubingcitations
- 2019Faster release of lumen-loaded drugs than matrix-loaded equivalent in polylactic acid/halloysite nanotubescitations
- 20183D printed end of arm tooling (EOAT) of a robotic arm
- 2018Surface-modified halloysite nanotubes reinforced poly(lactic acid) for use in biodegradable coronary stentscitations
- 2018Material considerations for fused-filament fabrication of solid dosage formscitations
- 2018Investigation of miscibility estimation methods between indomethacin and poly(vinylpyrrolidone-co-vinyl acetate)citations
- 2018Degradable nanocomposites for fused filament fabrication applicationscitations
- 2017Halloysite nanotube reinforced polylactic acid compositecitations
- 2016The effect of the mixing routes of biodegradable polylactic acid and polyhydroxybutyrate nanocomposites and compatibilised nanocompositescitations
- 2014The effect of processing conditions for polylactic acid based fibre composites via twin-screw extrusioncitations
- 2014Effect of Compatibilizer Content on the Mechanical Properties of Bioplastic Composites via Hot Melt Extrusioncitations
- 2014Improvement in mechanical properties of grafted polylactic acid composite fibers via hot melt extrusioncitations
- 2014Melt Processing of Bioplastic Composites via Twin Screw Extrusion and Injection Moldingcitations
- 2013Mechanical and biodegradation performance of short natural fibre polyhydroxybutyrate compositescitations
- 2011Assessing the effect of selected photoinitiators on the properties of photopolymerised temperature sensitive hydrogels
- 2011Nano-enhanced food contact materials and the in vitro toxicity to human intestinal cells of nano-ZnO at low dose
- 2011Nano-enhanced food contanct materials and the in vitro toxicity to human intestinal cells of nano-ZnO at low dose.
- 2010Physical and mechanical properties of blends based on poly (dl-lactide), poly (l-lactide-glycolide) and poly (ε-caprolactone)citations
- 2010In vitro degradation and drug release from polymer blends based on poly(dl-lactide), poly(l-lactide-glycolide) and poly(ε-caprolactone)citations
- 2010Characterisation of the effects of a titanium micro particle filler on a polyether-block-amide host matrixcitations
- 2009Development and characterisation of an agar-polyvinyl alcohol blend hydrogelcitations
- 2008Characterisation and controlled drug release from novel drug-loaded hydrogelscitations
- 2008The significance of variation in extrusion speeds and temperatures on a PEO/PCL blend based matrix for oral drug deliverycitations
- 2007Preparation of monolithic matrices for oral drug delivery using a supercritical fluid assisted hot melt extrusion processcitations
- 2007The incorporation of an organically modified layered silicate in monolithic polymeric matrices produced using hot melt extrusioncitations
- 2007The synthesis, swelling behaviour and rheological properties of chemically crosslinked thermosensitive copolymers based on N-isopropylacrylamidecitations
- 2006The use of Agar as a novel filler for monolithic matrices produced using hot melt extrusioncitations
- 2006Lower critical solution temperature control and swelling behaviour of physically crosslinked thermosensitive copolymers based on N-isopropylacrylamidecitations
Places of action
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article
Characterisation and controlled drug release from novel drug-loaded hydrogels
Abstract
<p>Hydrogel based devices belong to the group of swelling controlled drug delivery systems. Temperature responsive poly(N-isopropylacrylamide)-poly(vinylpyrrolidinone) random copolymers were produced by free radical polymerisation, using 1-hydroxycyclohexylphenyketone as an ultraviolet-light sensitive initiator, and poly(ethylene glycol) dimethacrylate as the crosslinking agent (where appropriate). The hydrogels were synthesised to have lower critical solution temperatures (LCST) near body temperature, which is favourable particularly for 'smart' drug delivery applications. Two model drugs (diclofenac sodium and procaine HCl) were entrapped within these xerogels, by incorporating the active agents prior to photopolymerisation. The properties of the placebo samples were contrasted with the drug-loaded copolymers at low levels of drug integration. Modulated differential scanning calorimetry (MDSC), attenuated total reflectance Fourier transform infrared spectroscopy (ATR-FTIR) and atomic force microscopy (AFM) were used to investigate the influence of the drugs incorporated on the solid-state properties of the xerogels. MDSC and swelling studies were carried out to ascertain their effects on the LCST and swelling behaviour of the hydrated samples. In all cases, drug dissolution analysis showed that the active agent was released at a slower rate at temperatures above the phase transition temperature. Finally, preliminary in vitro cytotoxicity evaluations were performed to establish the toxicological pattern of the gels.</p>