| People | Locations | Statistics |
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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Rodrigues, João
Universidade da Madeira
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (25/25 displayed)
- 2024Epidemiological and clinical trends of visceral leishmaniasis in Portugal: retrospective analysis of cases diagnosed in public hospitals between 2010 and 2020citations
- 2023Biological Effects in Cancer Cells of Mono- and Bidentate Conjugation of Cisplatin on PAMAM Dendrimers: A Comparative Studycitations
- 2023Experimental characterization of the nonlinear thermomechanical behaviour of refractory masonry with dry jointscitations
- 2023Target-Specific Delivery and Bioavailability of Pharmaceuticals via Janus and Dendrimer Particlescitations
- 2023Carbon dots and dendrimers nanohybrids: from synthesis to applicationscitations
- 2022Synthesis approach-dependent antiviral properties of silver nanoparticles and nanocompositescitations
- 2022New insights into ruthenium(ii) metallodendrimers as anticancer drug nanocarriers: from synthesis to preclinic behaviourcitations
- 2022Dendrimers and dendrimersomes as a novel tool for effective drug delivery applicationscitations
- 2022Strain-modulated optical response in 2D MoSe2 made by Na-assisted CVD on glasscitations
- 2021Use of Half-Generation PAMAM Dendrimers (G0.5-G3.5) with Carboxylate End-Groups to Improve the DACHPtCl(2) and 5-FU Efficacy as Anticancer Drugscitations
- 2021Efficient reSe2 photodetectors with CVD single-crystal graphene contactscitations
- 2021Cytocompatible cellulose nanofibers from invasive plant species Agave americana L. and Ricinus communis L.: a renewable green source of highly crystalline nanocellulosecitations
- 2020A Review on Thermoplastic or Thermosetting Polymeric Matrices Used in Polymeric Composites Manufactured with Banana Fibers from the Pseudostemcitations
- 2019Exploration of biomedical dendrimer space based on in-vivo physicochemical parameters: Key factor analysis (Part 2)citations
- 2018Mechanical Properties of Alumina Nanofilled Polymeric Composites Cured with DDSA and MNAcitations
- 2018Poly(alkylidenimine) Dendrimers Functionalized with the Organometallic Moiety [Ru(η5-C5H5)(PPh3)2]+ as Promising Drugs Against Cisplatin-Resistant Cancer Cells and Human Mesenchymal Stem Cellscitations
- 2018Recent therapeutic applications of the theranostic principle with dendrimers in oncologycitations
- 2017The influence of curing agents in the impact properties of epoxy resin nanocompositescitations
- 2016Effect of irregular shaped nanoalumina on the enhancement of mechanical properties of epoxy resin nanocomposites using DDM as hardenercitations
- 2015Octadecyl functionalized core-shell magnetic silica nanoparticle as a powerful nanocomposite sorbent to extract urinary volatile organic metabolitescitations
- 2015PAMAM Dendrimer/pDNA Functionalized-Magnetic Iron Oxide Nanoparticles for Gene Deliverycitations
- 2012The Effect of PAMAM Dendrimers on Mesenchymal Stem Cell Viability and Differentiationcitations
- 2012Injectable and biodegradable hydrogels: gelation, biodegradation and biomedical applicationscitations
- 2011ChemInform Abstract: Poly(alkylidenamines) Dendrimers as Scaffolds for the Preparation of Low‐Generation Ruthenium Based Metallodendrimers
- 2008Visible-light photolytic synthesis of multinuclear and dendritic iron-nitrile cationic complexes
Places of action
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article
Octadecyl functionalized core-shell magnetic silica nanoparticle as a powerful nanocomposite sorbent to extract urinary volatile organic metabolites
Abstract
In this present study, magnetic Fe3O4@SiO2 nanoparticles (MNPs) functionalized with octadecyl groups (Fe3O4@SiO2-C-18 NPs) were synthesized, characterized and employed, for the first time, as powerful nanosorbent to extract endogenous volatile organic metabolites (EVOMs) namely, hexanal, heptanal, decanal, benzaldehyde, 4-heptanone, 5-methyl-2-furfural and phenol, described as potential biomarkers of cancer, from human urine. By using co-precipitation, surface modification methods, the carbon-ferromagnetic nanocomposite was synthesized and characterized by infrared spectrum (IR) and transmission electron microscopy (TEM). By coupling with gas chromatography-mass spectrometry (GC-qMS), a reliable, sensitive and cost-effective method was validated. To test the extraction efficiency of the carbon-ferromagnetic nanocomposite toward urinary EVOMs experimental variables affecting the extraction performance,including nanosorbent amount, adsorption time, elution time, and nature of elution solvent, were investigated in detail. The extraction process was performed by dispersing Fe3O4@SiO2-C18 NPs into working solution containing targeted VOMs, and into urine samples, and then eluted with an adequate organic solvent. The eluate was collected, concentrated and analyzed by GC-qMS. Under the optimized conditions, the LODs and LOQs achieved were in the range of 9.7-57.3 and 32.4-190.9 ng/mL, respectively. Calibration curves were linear (r(2) >= 0.988) over the concentration ranges from 0.25 to 250 ng/mL. In addition, a satisfying reproducibility was achieved by evaluating the intra- and inter-day precisions with relative standard deviations (RSDs) less than 3 and 11%, respectively. The method also afforded satisfactory results in terms of the matrix effect (72.8-96.1%) and recoveries (accuracy) higher than 75.1% for most of the studied EVOMs. The Fe3O4@SiO2-Cis NPs-based sorbent extraction combined with GC-qMS revealed that the new nanosorbent had a strong ability to retain the target metabolites providing a new, reliable and high throughput strategy for isolation of targeted EVOMs in human urine, suggesting their potential to be applied in other EVOMs.