| People | Locations | Statistics |
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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Zreiqat, Hala
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (16/16 displayed)
- 2024Unraveling the influence of channel size and shape in 3D printed ceramic scaffolds on osteogenesiscitations
- 2024Engineering antibacterial bioceramicscitations
- 2023Design and evaluation of 3D-printed Sr-HT-Gahnite bioceramic for FDA regulatory submissioncitations
- 2023Discovering an unknown territory using atom probe tomographycitations
- 2021Redefining architectural effects in 3D printed scaffolds through rational design for optimal bone tissue regenerationcitations
- 2021Personalized Baghdadite scaffoldscitations
- 2021Highly substituted calcium silicates 3D printed with complex architectures to produce stiff, strong and bioactive scaffolds for bone regenerationcitations
- 2021Development of a bioactive and radiopaque bismuth doped baghdadite ceramic for bone tissue engineeringcitations
- 2020On design for additive manufacturing (DAM) parameter and its effects on biomechanical properties of 3D printed ceramic scaffoldscitations
- 2016Efficacy of novel synthetic bone substitutes in the reconstruction of large segmental bone defects in sheep tibiaecitations
- 2016Design and Fabrication of 3D printed Scaffolds with a Mechanical Strength Comparable to Cortical Bone to Repair Large Bone Defectscitations
- 2015Micro-poro-elasticity of baghdadite-based bone tissue engineering scaffolds: A unifying approach based on ultrasonics, nanoindentation, and homogenization theorycitations
- 2015Micro-poro-elasticity of baghdadite-based bone tissue engineering scaffolds:A unifying approach based on ultrasonics, nanoindentation, and homogenization theory
- 2014Micro-elasticity of porous ceramic baghdadite
- 2010The influence hydroxyapatite nanoparticle shape and size on the properties of biphasic calcium phosphate scaffolds coated with hydroxyapatite-PCL compositescitations
- 2009The effect of mesoporous bioactive glass on the physiochemical, biological and drug-release properties of poly(dl-lactide-co-glycolide) filmscitations
Places of action
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article
Development of a bioactive and radiopaque bismuth doped baghdadite ceramic for bone tissue engineering
Abstract
<p>Baghdadite (Ca<sub>3</sub>ZrSi<sub>2</sub>O<sub>9</sub>, BAG), is a Zr-doped calcium silicate that has outstanding bioactivity both in vitro and in vivo. Bioceramic scaffolds should be sufficiently radiopaque to be distinguishable in vivo from surrounding bone structures. To enhance the radiopacity of BAG, this study investigated the effect of incorporating bismuth ions into its crystalline structure (Bi<sub>x</sub>Ca<sub>3-x</sub>ZrSi<sub>2</sub>O<sub>9</sub>, x = 0, 0.1, 0.2, 0.5; BAG, Bi0.1-BAG, Bi0.2-BAG, Bi0.5-BAG, respectively). Monophasic baghdadite was retained after bismuth ion incorporation up to x = 0.2 at calcination temperatures of 1350 °C. When pressed and sintered, energy dispersive x-ray spectroscopy showed that BAG and Bi0.1-BAG retained crystalline homogeneity, but Bi0.2-BAG formed zirconium-rich crystalline regions. BAG, Bi0.1-BAG and Bi0.2-BAG exhibited non-degradation after 56 days of immersion in culture medium. Bi0.1-BAG exhibited the lowest change in culture medium pH (+0.0), compared to BAG (+0.7) and Bi0.2-BAG (+0.2) after 56 days of culture media immersion. Bi0.1-BAG exhibited similar strength and modulus to BAG (σ: 200–290 MPa; E: 4–5 GPa), and significantly higher compressive strength and modulus versus Bi0.2-BAG (σ: 150–200 MPa; E: 3.5–4 GPa) across 56 days of aqueous immersion. In vitro studies using primary human bone derived cells (HOBs) demonstrated a significant increase in HOBs proliferation when cultured on Bi0.1-BAG for seven days compared to BAG and Bi0.2-BAG. Importantly, Bi0.1-BAG showed increased radiopacity by ~33%, when compared to BAG, and by ~115% when compared to biphasic calcium phosphate. The properties of Bi0.1-BAG show promise for its use as a bioactive ceramic with sufficient radiopacity for treatment of bone defects.</p>