| People | Locations | Statistics |
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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Zreiqat, Hala
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (16/16 displayed)
- 2024Unraveling the influence of channel size and shape in 3D printed ceramic scaffolds on osteogenesiscitations
- 2024Engineering antibacterial bioceramicscitations
- 2023Design and evaluation of 3D-printed Sr-HT-Gahnite bioceramic for FDA regulatory submissioncitations
- 2023Discovering an unknown territory using atom probe tomographycitations
- 2021Redefining architectural effects in 3D printed scaffolds through rational design for optimal bone tissue regenerationcitations
- 2021Personalized Baghdadite scaffoldscitations
- 2021Highly substituted calcium silicates 3D printed with complex architectures to produce stiff, strong and bioactive scaffolds for bone regenerationcitations
- 2021Development of a bioactive and radiopaque bismuth doped baghdadite ceramic for bone tissue engineeringcitations
- 2020On design for additive manufacturing (DAM) parameter and its effects on biomechanical properties of 3D printed ceramic scaffoldscitations
- 2016Efficacy of novel synthetic bone substitutes in the reconstruction of large segmental bone defects in sheep tibiaecitations
- 2016Design and Fabrication of 3D printed Scaffolds with a Mechanical Strength Comparable to Cortical Bone to Repair Large Bone Defectscitations
- 2015Micro-poro-elasticity of baghdadite-based bone tissue engineering scaffolds: A unifying approach based on ultrasonics, nanoindentation, and homogenization theorycitations
- 2015Micro-poro-elasticity of baghdadite-based bone tissue engineering scaffolds:A unifying approach based on ultrasonics, nanoindentation, and homogenization theory
- 2014Micro-elasticity of porous ceramic baghdadite
- 2010The influence hydroxyapatite nanoparticle shape and size on the properties of biphasic calcium phosphate scaffolds coated with hydroxyapatite-PCL compositescitations
- 2009The effect of mesoporous bioactive glass on the physiochemical, biological and drug-release properties of poly(dl-lactide-co-glycolide) filmscitations
Places of action
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article
Discovering an unknown territory using atom probe tomography
Abstract
<p>Here we report the first atom probe study to reveal the atomic-scale composition of in vivo bone formed in a bioceramic scaffold (strontium-hardystonite-gahnite) after 12-month implantation in a large bone defect in sheep tibia. The composition of the newly formed bone tissue differs to that of mature cortical bone tissue, and elements from the degrading bioceramic implant, particularly aluminium (Al), are present in both the newly formed bone and in the original mature cortical bone tissue at the perimeter of the bioceramic implant. Atom probe tomography confirmed that the trace elements are released from the bioceramic and are actively transported into the newly formed bone. NanoSIMS mapping, as a complementary technique, confirmed the distribution of the released ions from the bioceramic into the newly formed bone tissue within the scaffold. This study demonstrated the combined benefits of atom probe and nanoSIMS in assessing nanoscopic chemical composition changes at precise locations within the tissue/biomaterial interface. Such information can assist in understanding the interaction of scaffolds with surrounding tissue, hence permitting further iterative improvements to the design and performance of biomedical implants, and ultimately reducing the risk of complications or failure while increasing the rate of tissue formation. <br/></p><p>Statement of significance: The repair of critical-sized load-bearing bone defects is a challenge, and precisely engineered bioceramic scaffold implants is an emerging potential treatment strategy. However, we still do not understand the effect of the bioceramic scaffold implants on the composition of newly formed bone in vivo and surrounding existing mature bone. This article reports an innovative route to solve this problem, the combined power of atom probe tomography and nanoSIMS is used to spatially define elemental distributions across bioceramic implant sites. We determine the nanoscopic chemical composition changes at the Sr-HT Gahnite bioceramic/bone tissue interface, and importantly, provide the first report of in vivo bone tissue chemical composition formed in a bioceramic scaffold.</p>