• Patra, Maxcimilan
• Saha, Rajat
• Mukherjee, Suprabhat
• Sarkar, Keka
• Bhowmick, Arpita
• Ghosh, Narendra Nath
• Mandal, Jishu
• Ghosh, Angshuman
• Dubey, Soumen Kumar

Abstract

<jats:title>Abstract</jats:title><jats:p>We have shown solvent‐ and substrate‐dependent chiral inversion of a few glycoconjugate supramolecules. (<jats:italic>Z</jats:italic>)‐F‐Gluco, in which <jats:sc>d</jats:sc>‐glucosamine has been attached chemically to Cbz‐protected <jats:sc>l</jats:sc>‐phenylalanine at the C terminus, forms a self‐healing hydrogel through intertwining of the nanofibers wherein the gelators undergo lamellar packing in the β‐sheet secondary structures with a single chiral handedness. Dihybrid (<jats:italic>Z</jats:italic>)‐F‐gluco nanocomposite gel was prepared by in‐situ formation of silver nanoparticles AgNPs in the gel; this enhances the mechanical properties of the composite gel through physical crosslinking without altering the packing pattern. In contrast, (<jats:italic>Z</jats:italic>)‐L‐gluco bearing an <jats:sc>l</jats:sc>‐leucine moiety does not form a hydrogel but an organogel. Interestingly, the chiral handedness of the aggregates of (<jats:italic>Z</jats:italic>)‐L‐gluco can be reversed by choosing suitable solvents. In addition to self‐healing behavior, (<jats:italic>Z</jats:italic>)‐L‐gluco gel revealed shape persistency. Further, (<jats:italic>Z</jats:italic>)‐F‐gluco hydrogel is benign, nontoxic, non‐immunogenic, and non‐allergenic in animal cells. AgNP‐loaded (<jats:italic>Z</jats:italic>)‐F‐gluco hydrogel showed antibacterial activity against both Gram‐positive and Gram‐negative bacteria.</jats:p>

Topics

• nanoparticle
• nanocomposite
• impedance spectroscopy
• silver
• gelation